Its simpler to identify medicines by their components, since many of them are essentially the same thing marketed under different brand names. Nexgard Spectra. Congratulations on the new kitten. We need more people like you. (No judgment if you didnt see that section: I know its a very long article and I expect most people are looking for a quick or specific answer and dont actually read the whole thing ?.) Substantially improves the clinical signs of Flea Allergy Dermatitis in dogs. I found this after hearing about the Seresto issues and how they werent accurately reporting data. Permethrin is a synthetic of Pyrethrin, which is derived from the chrysanthemum flower. Its reasonable to think that a larger sample size of dogs would yield greater prevalence of side effects, and a smaller sample size would yield fewer. I have a 3 year old and an 11 week old Australian Shepherd. As noted in an article by Dog Aware:Advantage Multi, which combines imidacloprid for flea control with moxidectin for heartworm prevention, was found to cause no side effects when applied topically to affected dogs even at 5 times the recommended dose, but ingesting less than half the recommended topical dose caused extreme toxicity leading to coma in four of five dogs.. Although it would be very hard to determine exactly which component of a combination medication your Collie is reacting to, your girl might be less likely to have a reaction to Interceptor (regular, not Plus), as it only has one active ingredient as opposed to the two active ingredients in Sentinel. I grew up in Michigan, and we always discontinued pest products during the cold season. Could you send the link to that article you found? The other thing is he is small for a male (30 lbs) and the Sentinel dose is for 26-50 lbs, which I think is part of the problem. My vet wants to give him a vaccine (?) Last year I used Frontline Plus with no issues. Personally, my Roughs have sensitive skin plus I have a household cat, so Id try Frontline Gold first. . -It is long-lasting and provides protection against fleas for up to 35 days. I just quote the ones who are knowledgeable about MDR1. Were bringing home an MDR1 heterozygous smooth boy this weekend so Ill definitely be saving the link to this page. For anyone who prefers to use organic instead of chemical products or would like a repellent in addition to what you are already using, this is the flea and tick spray for you! Since Collies and cats go together so well, I have to include this caution for cats: Some ingredients used to kill ticks, such as permethrin (used in K9 Advantix and other products) and amitraz (used in Certifect and the Preventic collar), are toxic to cats, which can be a problem in a household that includes both, especially if they are friendly with each other. If you have cats that share sleeping space with and/or like to groom your dogs, Advantix is probably not the best product for you. Now: $92.79. Have you had any issues with Seresto? The flea pills and chews all contain a pesticide called isoxazoline, the FDA said . An added benefit is it has been around long enough that cheaper generic products are available, some of which Ive tried and found to be as effective as Frontline. Please help! The Wondercide website says, We recommend testing any new product you introduce to your pet or environment eight hours prior to a full application to ensure there are no sensitivities. With cedar oil being the main ingredient, it should be relatively safe; but its best to be cautious, especially as your girl has proven to be so sensitive. Additionally, it can be used to treat and control sarcoptic mange. Bear with me for a little pharmaceutical science, which I promise is important and will make sense in the end! Hi Vicki, We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. But it doesnt hurt mammals. The fleas have to bite for the product to work, and in some places fleas seem to have developed a resistance to it. Dr. Morgan concluded her story with: Be your pets advocate. Effective against ticks that may carry debilitating diseases like ehrlichiosis, anaplasmosis, and rickettsiosis 2. If you have a dog you suspect has Giardia, it really is best to see a veterinarian. You probably already know Frontline Gold can be toxic to cats, since it has a caution on the label, but this is only really a concern if you have a cat who cuddles with or grooms your dogs. In a laboratory study, the product was . In the past she was prescribed Bravecto and experienced what I could only assume to be neurological side effects/symptoms such as sporadic limping, weakness and sensitivity to human contact. It probably is the safest as it is aimed only at preventing heartworm. We had a collie before this one and she had seizures from a treatment Thanks again Priscilla. I have a new Collie-mix with bi-coloured coat. Hi Emily Waxman and Brooks both recommend it. Simparica is not a heartworm preventive whereas Simprica TRIO works as a heartworm control treatment. Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewable-for protection against heartworm disease, ticks & fleas, roundworms & hookworms.. One chewable tablet provides month-long protection for all dogs over 8 weeks old and weighing 2.8 pounds or more. Flea Treatment and Prevention In a wellcontrolled laboratory study, SIMPARICA TRIO began to kill fleas at However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. Tap to zoom. I really do not think there is a safe heart worm medicine out there for a MDR1 collie. Thanks. While Trifexis technically doesnt have any MDR1-specific cautions, its combination of active ingredients make it a bit more risky for dogs who are already sensitive to certain chemicals and just prone to sensitivity in general. Is Simparica trio safe for dogs with the MDR1 gene? Thank you! That told me hes pretty confident in it and struck me as a bold move from a marketing standpoint. Some swear by food grade DE (diatomaceous earth) as a natural dewormer of roundworms, hookworms, whipworms, and even tapeworms. . As the agency explained: Although FDA scientists carefully evaluate an animal drug prior to approval, there is the potential for new information to emerge after marketing, when the product is used in a much larger population. (New drugs continue to be highly monitored for the first three years following their release.). Based on Zodiacs ingredients, it should be relatively safe for an Aussie although it may be a bit harsher than some others as the label indicates it should only be used on dogs 6 months or older. The vet said at first that was not possible and checked with their pharmaceutical representative who said that was not possible. After talking to a variety of Collie people, Frontline seems to be the most trusted of the topical flea/tick products available. Is credelio considered safe when using interceptor? I had started my GSD on Revolution, but really always liked Frontline better and since that seems to cover more ticks and still protect us from unwanted mites I probably will lean toward that. Its rare for such strong reactions to come about as a result of Interceptor being given at the recommended dosage usually adverse reactions like that would only be seen in an overdose but its not impossible. . After 1 emergency vet visit and a number of consultations with our primary care vet, we took him off simparica. However, while Panacur C can be used to treat Giardia, it is probably not enough to take care of it alone depending on its severity, and will work best in combination with an antibiotic. Unfortunately, it seems most people who lost their dogs to Seresto collars simply did not make the connection until it was too late. Dogs, 6 Month Supply. This product is not recommended for MDR1 dogs, as its main ingredient, dinotefuran, is a harsh pesticide. Your article was appreciated and helpful! Best of luck! The majority of canines will be fine, but there are enough who will react. Any thoughts on either of these? Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. We do, however, have lots of deer ticks (also known as black legged ticks). Its safe for pregnant/nursing mother dogs and puppies as young as eight week. Thanks again for your time : ), Thank you for pointing that out! K9 Advantix II Flea, Tick and Mosquito Prevention for Dogs, 6 Doses. Its worth making a phone call to see what they would recommend for your pup. Happy to help! Dogs with the mutation lack a protein (P-glycoprotein) which is responsible for pumping the drugs from the brain. Vectras brag is that it repels and kills fleas, five kinds of ticks, flies, mosquitoes, and mites; however, its use is not worth its risk. I quoted a specific veterinarian who mentioned why she never diagnoses Nexgard and Heartgard together. And use same collar for a few months. Should I give them Trifexis or Sentinel Spectrum? However, it would be best to have a veterinarian collect a skin scraping to examine under a microscope and determine whether skin irritation is caused by demodectic or sarcoptic mites, as the causes and treatments differ between the two types. Based on your recommendations, I will not use Vectra. Wow! Simparica TRIO is a monthly chew with triple protection against the three biggest threats facing our dogs today - fleas and ticks, intestinal worms and deadl. ? I dont have much personal experience with this other than giving my MDR1 mutant/normal Collie girl veterinary-prescribed Carprofen when she hurt her paw. Simparica Trio (133) 133 Reviews | Answered Questions. Frontline Shield has Permethrin and Pyriproxifen, so my concern would be that those 2 ingredients together would be stronger and potentially cause skin irritation. I tried Seresto with my girl and she had a seizure. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Trifexis is perhaps the most well-known (and frequently peddled at veterinary clinics) of this combo category. It was the amount of ticks Ive been having to remove that lead me to your article! Altogether, the agency received 75,000 incident reports, the majority of which were complaints of skin reactions in both animals and humans. Simparica Trio treats and protects against harmful parasites. If youre concerned about a possible hormonal imbalance being triggered by Effifax, it might be worth looking into an alternate flea control product that does not contain Fipronil. Simparica Trio works against the same ticks as Nexgard and also protects your dog from heartworms, hookworms, and roundworms. These can come in a few different forms: monthly spot-on, a disposable collar, or a spray. It is such a relief to know that even if she tests positive there are options that are safe. I plan to switch him over to Trifexis also. While I dont believe it be quite as effective as the label says it is though that might have something to do with living in pest-ridden Florida I do find it to be very helpful. If this gene is mutated, it will create a defective protein, and consequently, drugs will remain and build up in the brain to toxic levels. Great Treats for Collies (Easy on the GI Tract), This article (authored by two veterinarians) is an excellent resource, it could suffer severe side effects and even die, this article I wrote about Border Collies, available online from pet supply stores such as Chewy, a link to a USA Today article about side effects resulting in seizures and even death, the USA Today headline (I get notifications on my phone) about Seresto collars. So, I now need a good flea/tick med and would rather not get another pill for her to take. Bravecto (Fluralaner) Appears Safe For Dogs With MDR1 Gene Mutation by: Anton (Bravecto (Fluralaner) is a long-acting oral flea and tick control drug.) Simparica Trio is replacing NexGard Spectra as your dog's monthly parasite protection. Is this vaccine something youve heard of? That being said, if a dog was known to be heartworm-negative and the dogs owner would remember to administer a daily dose, I think it could make a good alternative heartworm preventive. Though not meant for long-term treatment, it is excellent for short-term intervention in the case of severe infestations or for a dog who happened to pick up a few fleas on an outdoor ramble and is in need of some quick relief. Simparca TRiO is suitable to use for puppies and dogs over the age of 8 weeks old or older. It covers fleas, ticks, and heart worms. The bottom line is, its best to avoid giving your Collie Heartgard or a similar medication. We are waiting for the results from her test for the MDR1 gene. I follow this advice, since Im a safe-is-better-than-sorry person. enough to have 4 dogs like I do! I also have a 5 month Aussie who the current vet has on Bravecto 1-month and TriHeart. I would probably try something like Advantix II or Frontline Gold before Vectra. How can I prevent my dog from getting ticks? That being said, I do have to give the disclaimer that Im not a veterinarian myself. I have two beautiful rough collies & of course always want to keep them safe. I can live with that. Im hoping to get a Smoothie myself in the future. Not that I want to complicate things; its really just a case of sacrificing convenience on the altar of necessity. It was winter. We recently switched our dogs to a new product called Simparica Trio. I know youre very particular about the genetic health of your Collies, and I admire your breeding program. Ill list all the options I looked into (including several Ive personally tried), along with whether theyre considered safe to use, use with caution, or a complete no-no. Unfortunately, the fleas are fighting back. When reading about Seresto, their website said it doesnt work well on dogs with heavy coats, ie. Dash is MDR1 mutant/normal. If youre someone who lives in a tick-prone area or likes to take your dogs on woodland rambles (like me), this is a letdown. I have two Rough Collies who are MDR1 carriers and an Aussie mix, so I have a vested interest in everything Ive researched. Simaprica Trio is a multi-spectral treatment for dogs that treats external pests and infectious internal parasites. Last month I took her to a new vet and they gave us Simparica Trio for her f/t hwp. We actually live in New Hampshire and hike (off-leash) quite frequently. At least once a week or before we go walking down woodland trails, I also take the precaution to spray my dogs legs and lower body (and my shoes) with Natures Best or Natural Chemistry flea and tick repellent. My Vet told me Trifexis was safe to give them. Second, Id like to ask a question if you dont mind. Regardless of the heartworm product you choose, as the Institute of Pharmacology and Toxicology says, treatment of MDR1 mutant dogs with macrocyclic lactones in general requires particular caution. It really boils down to weighing the benefits of medications against the risks from internal parasites. Id like to understand why you chose the newer formulation with less external parasitic coverage variety so I can also make the best choice for my pup! Simparica claims to be safe for dogs or breeds sensitive to MDR1 ( including Collies, Australian Shepherds or Border Collies), stating "Simparica Trio and Simparica is well-tolerated in various breeds of dogs when used as directed, including dogs with deficient multidrug-resistant-protein". . Fortunately, there is a DNA test that will let you know whether your dog has this mutation. Simparica Trio is an all-in-one monthly chewable treatment for dogs. First, I want to thank you for the time and effort that went into writing this article. I doubt it as he was on leash and Im always watching him. Also I live in Michigan just outside Detroit so his walks consist of concrete sidewalks and no real wildlife to come across. Some parts of the U.S. now report a new strain of survivor flea that has developed a resistance to fipronil, the main ingredient in Frontline. I love that it quickly kills adult fleas andfour kinds of ticks: American dog tick, brown dog tick, lone star tick, and black-legged tick. Could that have been the cause of the seizure, even though she took it more than a month ago? Approved for use in dogs over the age of 8 weeks and above 2.8 lbs, please note that depending on the pest . In the United States, DEC (diethylcarbamazine) was sold as Filaribits or Nemacide, but they no longer appear to be on the market. Personally, I would be concerned about missing a daily dose. However, I have to state the disclaimer that even parasite protection products officially labeled safe from an MDR1 standpoint should really be designated safe-ish. Most of these products are chemical compounds, and as such have more potential to cause a reaction than just, well, water. We took her to a vet who is very experienced with collies (she helps with a rescue) and has assured me that Simpirica Trio is safe. We can eat it. Personally I use Frontline Plus and supplement weekly with a Natural Chemistry spray as a repellent, but I understand that might not be ideal for everyone depending on their situations. Astfel, produsul Simparica Trio Caini (40.1 - 60 kg), 3 x comprimate masticabile este fabricat i depozitat la standarde ridicate. Mar 2013. I tried to review a variety of the most well-known parasite protection products out there, but if I left out any you are curious about, leave a comment below! Im leaning toward Frontline Plus based on what you wrote. Observaciones clnicas de salud, Parmetros toma de muestras sanguneas para medidos farmacocintica. Is Simparica Trio safe for dogs with MDR1? We have an 11 year old tricolor rough coat collie. Thats a rough situation, and Im sorry you and your pup are going through this. Unlike many other external parasite treatments that only kill little bloodsuckers after theyve bitten the dog, K9 Advantix claims to kill them on contact. Parastar Plus is not something Ive personally used, but it should be safe as one of its active ingredients is Fipronil (which is in Frontline) and the other active ingredient, Cyphenothrin, is in the same family of drugs as Permethrin. In studies it started killing within four hours, and achieved 100% effectiveness in eight hours. It just depends on the individual dog. ivermectin, selamectin)? Tap to zoom. 5 A dog's reaction to flea bites may vary from sores and inflammation to hair loss. Dinotefuran in particular is a strong pesticide, and all 3 of those ingredients combined are harsh on sensitive skin. (MDR1 -/-) following single oral administration at 5 times the recommended dose. Im glad you found this information helpful. It is also used off-label to control sarcoptic mange and demodectic mange. ), In regards to your other question, heres what I found for you: Prinovox is the generic alternative to Advocate (in the UK and Australia) and Advantage Multi (in the US) both made by Bayer, just marketed by different names in different countries. (There are other places, but none more affordable that Ive found.) According to the Vet UK website, I actually ended up choosing Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). ? 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Think there is a DNA test that will let you know whether dog! 5 a dog & # x27 ; s reaction to Flea bites may vary from sores and to! Walks consist of concrete sidewalks and no real wildlife to come across lots of ticks... Really is best to see a veterinarian myself 100 % effectiveness in eight hours Flea! The brain substantially improves the clinical signs of Flea Allergy Dermatitis in dogs over the of! Do, however, have lots of deer ticks ( also known as black ticks. As a natural dewormer of roundworms, hookworms, and in some places fleas to... Until it was too late marketing standpoint the bottom line is, its best to see what would! Parmetros toma de muestras sanguneas para medidos farmacocintica to work, and rickettsiosis 2 Gold first dewormer of roundworms hookworms... Quite frequently health of your Collies, and even tapeworms that article you found suspect has Giardia, can! When reading about Seresto, their website said it doesnt work well on dogs heavy! 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